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研究領域

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AAV在心臟研究中的靶向策略【干貨篇】

AAV可在(zai)心臟組(zu)織有(you)效、持久、穩定、安(an)全地表(biao)達外源基因(yin)，因(yin)而在(zai)心臟基因(yin)治療策略中占據獨特優勢(shi)。在(zai)使用(yong)rAAV進行心臟研(yan)究時，正確選擇AAV血清型、啟(qi)動子(zi)以及(ji)注射方式是實驗順(shun)利開展的必備條(tiao)件。今(jin)天小(xiao)V就和(he)大家一起來學習一下AAV在(zai)心臟研(yan)究中的優化(hua)策略，以提(ti)高AAV的基因(yin)轉(zhuan)移效率。

+AAV在心臟研究中的靶向策略【應用篇(pian)】
2022-04-07

+AAV在心臟(zang)研究(jiu)中的應用及(ji)注(zhu)射方法
2020-03-23

+維真AAV病毒在高血(xue)壓(ya)腦出血(xue)中的應用
2020-03-15

心(xin)臟方面：

1.	Hypertension. (IF=7.713). Liu, Wen, Li, et.al. (2020). Oleic Acid Attenuates Ang II（Angiotensin II）-Induced Cardiac Remodeling by Inhibiting FGF23（Fibroblast Growth Factor 23.［中國醫學科學院阜外醫院 AAV9-Fgf23&AAV9-GFP 高血壓心臟重構］
2.	International Journal of Molecular Medicine. (IF=3.098). Huang, et.al. (2019). Redd1 protects against post-infarction cardiac dysfunction by targeting apoptosis and autophagy.［華中科技大學同濟醫學院附屬協和醫院 AAV9-Redd1 & AAV9-GFP 心機梗死MI］
3.	Frontiers in Pharmacology. (IF=4.225). Shen, et.al. (2019). Downregulation of miR-146a Contributes to Cardiac Dysfunction Induced by the Tyrosine Kinase Inhibitor Sunitinib.［河北醫科大學 AAV9-cTNT-GFP-miR-146a & AV-miR-146a SNT-誘導的心臟收縮障礙］
4.	Journal of Molecular and Cellular Cardiology. (IF=4.133). Wu, et.al. (2019). The protective effect of high mobility group protein HMGA2 in pressure overload-induced cardiac remodeling.［武漢大學 AAVs & Ads心臟重構］
5.	Biochemical and Biophysical Research Communications. (IF=2.985). Yang, et.al. (2018). Vaspin alleviates myocardial ischaemia/reperfusion injury via activating autophagic ?ux and restoring lysosomal function.［山東大學齊魯醫院 AAV-vaspin & Ad-RFP-GFP-LC3 心臟］

血管方面(mian)：

1.	Arteriosclerosis, Thrombosis, and Vascular Biology. (IF=6.604). Zhao, et.al. (2019). ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia-Induced Pulmonary Hypertension.［山東大學齊魯醫院 AAV2-SM22α-ALDH2 & AAV1-ICAM2-ALDH2 低氧性肺動脈高壓HPH］
2.	Journal of Molecular and Cellular Cardiology. (IF=4.133). Sun, et.al. (2019). LncRNA H19 promotes vascular inflammation and abdominal aortic aneurysm formation by functioning as a competing endogenous RNA.［南方醫科大學南方醫院 AAV9-H19 腹主動脈瘤AAA］
3.	Journal of Cerebral Blood Flow & Metabolism. (IF=5.681). Li, et.al. (2019). Overexpression of LH3 reduces the incidence of hypertensive intracerebral hemorrhage in mice.［中國醫學科學院阜外醫院 AAV9-LH3-p2A-GFP 高血壓性腦出血ICH］
4.	Arteriosclerosis, Thrombosis, and Vascular Biology. (IF=6.604). Zhong, et.al. (2019). SM22α (Smooth Muscle 22α) Prevents Aortic Aneurysm Formation by Inhibiting Smooth Muscle Cell Phenotypic Switching Through Suppressing Reactive Oxygen Species/NF-κB (Nuclear Factor-κB).［南方醫科大學南方醫院 AAV9-SM22α 腹主動脈瘤AAA］

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