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研究領域

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AAV在腦組織中的靶向策略（干貨篇）

+神經研究的重要工具——DREADDs技術
2019-11-12

+北大李毓龍研究員課題組開發神經遞質熒光探針
2019-04-09

+維真生物AAV病毒在神經中的優秀案例分享
2021-09-26

+維真生物AAV(retro)產品優秀案例分享
2021-09-26

1.	Nature Communications. (IF=12.121). Xu, et.al. (2020). CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis.［中國科學院昆明動物所 AAV9-shRNA(circGRIA1) & AAV9-shRNA(control) 靈長類動物恒河猴腦衰老］
2.	Science Advances. (IF=13.116). Sun, et.al. (2020). Development of a CRISPR-SaCas9 system for projection- and function-specific gene editing in the rat brain.［北京大學 CRISPR-saCas9 基因編輯雄性SD大鼠特定神經元群］
3.	The Journal of Neuroscience. (IF=5.673). Zingg B, et.al. (2020). Synaptic Specificity and Application of Anterograde Transsynaptic AAV for Probing Neural Circuitry.［南加利福尼亞大學scAAV1 hSyn-Cre & AAV1-hSyn-Flp & AAVretro-hSyn-Cre & AAV1-EF1a-DIO-Flp-WPRE & AAVretro-hSyn-GFP-WPRE 順向跨單級突觸示蹤］
4.	Molecular Psychiatry. (IF=12.384). li, et.al. (2020). Programmed cell death 4 as an endogenous suppressor of BDNF translation is involved in stress-induced depression.［山東大學 AAV9-CMV-mPdcd4-P2A-GFP 抑郁癥］
5.	Biological Psychiatry. (IF=12.095). Zhang, et.al. (2020). Reduced neuronal cAMP in the nucleus accumbens damages blood-brain barrier integrity and promotes stress vulnerability.［中國藥科大學 Dox 誘導性AAV2/9-shRNA-Adcy5 or AAV2/9-shRNA 抑郁癥］
6.	Cell Reports. (IF=8.109). Ma, et.al. (2019). Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation. ［北京大學 AAV2 retro-hSyn-Cre-GFP & AAV2-CAG-DIO-BDNF-mCherry-3*flag 慢性疼痛］
7.	Cell. (IF=38.637). Fan, et.al. (2019). Stress-Induced Metabolic Disorder in Peripheral CD4+T Cells Leads to Anxiety-like Behavior. ［浙江大學 AAV9-GFAP-GFP-miR30-shRNA(mAdora1) & AAV8-MBP-GFP-miR30-shRNA(mAdora1) & AAV8-MBP-GFP-miR30-shRNA(scramble) 焦慮精神疾病］
8.	Neuron. (IF=14.415). Feng, et.al. (2019). A Genetically Encoded Fluorescent Sensor for Rapid and Speci?c In Vivo Detection of Norepinephrine.［北京大學AAV9-hSyn-NE1m & NE1h and AAV9-hsyn-tTA 去甲腎上腺素神經遞質探針］
9.	Cell. (IF=38.637). Sun, et.al. (2018). A Genetically Encoded Fluorescent Sensor Enables Rapid and Speci?c Detection of Dopamine in Flies,Fish, and Mice.［北京大學AAV-hSyn-DA1m & DA1h 多巴胺神經遞質探針］
10.	Behavioural Neurology. (IF=2.093). Qu, et.al. (2018). MST1 Suppression Reduces Early Brain Injury by Inhibiting the NF-κB/MMP-9 Pathway after Subarachnoid Hemorrhage in Mice.［第三軍醫大學西南醫院神經外科 MST1 AAV-4 in 1 shRNA-GFP 腦室注射蛛網膜下腔出血］
11.	Neuron. (IF=14.415). Zingg B, et.al. (2017). AAV-Mediated Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense Behaviors.［南加利福尼亞大學AAV1-EF1a-DIO-Flp 順向跨單級突觸示蹤］